5-HTTLPR moderates the association between interdependence and brain responses to mortality threats.

ABSTRACT: While behavioral research suggests an association between cultural worldview and decreased anxiety of death, the underlying neurobiological mechanisms remain unclear. Using functional MRI, we investigated whether and how the serotonin transporter promoter polymorphism (5-HTTLPR), which has been associated with mental disorders such as anxiety and depression, moderates the associations between a cultural trait (i.e., interdependence) and self-report of death anxiety/depression and between interdependence and brain responses to mortality threats. Long/long and short/short allele carriers of the 5-HTTLPR were scanned using fMRI while they performed a one-back task on death-related, death-unrelated negative, and neutral words. Participants' interdependence and death anxiety/depression were ass

SUBMITTER: Luo S 

PROVIDER: S-EPMC6866803 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature