Gender differences in healthy aging and Alzheimer's Dementia: A ¹⁸ F-FDG-PET study of brain and cognitive reserve.

ABSTRACT: Cognitive reserve (CR) and brain reserve (BR) are protective factors against age-associated cognitive decline and neurodegenerative disorders. Very limited evidence exists about gender effects on brain aging and on the effect of CR on brain modulation in healthy aging and Alzheimer's Dementia (AD). We investigated gender differences in brain metabolic activity and resting-state network connectivity, as measured by ¹⁸ F-FDG-PET, in healthy aging and AD, also considering the effects of education and occupation. The clinical and imaging data were retrieved from large datasets of healthy elderly subjects (HE) (225) and AD patients (282). In HE, males showed more extended age-related reduction of brain metabolism than females in frontal medial cortex. We also found differences in bra

SUBMITTER: Malpetti M 

PROVIDER: S-EPMC6866811 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature