Fronto-temporal connectivity predicts cognitive empathy deficits and experiential negative symptoms in schizophrenia.

ABSTRACT: Impaired cognitive empathy is a core social cognitive deficit in schizophrenia associated with negative symptoms and social functioning. Cognitive empathy and negative symptoms have also been linked to medial prefrontal and temporal brain networks. While shared behavioral and neural underpinnings are suspected for cognitive empathy and negative symptoms, research is needed to test these hypotheses. In two studies, we evaluated whether resting-state functional connectivity between data-driven networks, or components (referred to as, inter-component connectivity), predicted cognitive empathy and experiential and expressive negative symptoms in schizophrenia subjects. Study 1: We examined associations between cognitive empathy and medial prefrontal and temporal inter-component connectivity at

SUBMITTER: Abram SV 

PROVIDER: S-EPMC6866816 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature