Diversity of functional connectivity patterns is reduced in propofol-induced unconsciousness.

ABSTRACT:

Introduction

Recent evidence suggests that the conscious brain is characterized by a diverse repertoire of functional connectivity patterns while the anesthetized brain shows stereotyped activity. However, classical time-averaged methods of connectivity dismiss dynamic and temporal characteristics of functional configurations. Here we demonstrate a new approach which characterizes time-varying patterns of functional connectivity at the subsecond time scale.

Methods

We introduce phase-lag entropy (PLE), a measure of the diversity of temporal patterns in the phase relationships between two signals. The proposed measure was applied to multichannel electroencephalogram (EEG), which were recorded from two distinct experimental settings: (1) propofol was administrated at a constan

SUBMITTER: Lee H 

PROVIDER: S-EPMC6866820 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature