Distinct white matter injury associated with medial temporal lobe atrophy in Alzheimer's versus semantic dementia.

ABSTRACT: This study aims at further understanding the distinct vulnerability of brain networks in Alzheimer's disease (AD) versus semantic dementia (SD) investigating the white matter injury associated with medial temporal lobe (MTL) atrophy in both conditions. Twenty-six AD patients, twenty-one SD patients, and thirty-nine controls underwent a high-resolution T1-MRI scan allowing to obtain maps of grey matter volume and white matter density. A statistical conjunction approach was used to identify MTL regions showing grey matter atrophy in both patient groups. The relationship between this common grey matter atrophy and white matter density maps was then assessed within each patient group. Patterns of grey matter atrophy were distinct in AD and SD but included a common region in the MTL, encompassi

SUBMITTER: Bejanin A 

PROVIDER: S-EPMC6866822 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature