Whole-brain structural connectivity in dyskinetic cerebral palsy and its association with motor and cognitive function.

ABSTRACT: Dyskinetic cerebral palsy (CP) has long been associated with basal ganglia and thalamus lesions. Recent evidence further points at white matter (WM) damage. This study aims to identify altered WM pathways in dyskinetic CP from a standardized, connectome-based approach, and to assess structure-function relationship in WM pathways for clinical outcomes. Individual connectome maps of 25 subjects with dyskinetic CP and 24 healthy controls were obtained combining a structural parcellation scheme with whole-brain deterministic tractography. Graph theoretical metrics and the network-based statistic were applied to compare groups and to correlate WM state with motor and cognitive performance. Results showed a widespread reduction of WM volume in CP subjects compared to controls and a more localize

SUBMITTER: Ballester-Plane J 

PROVIDER: S-EPMC6866837 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature