Anomalous single-subject based morphological cortical networks in drug-naive, first-episode major depressive disorder.

ABSTRACT: Major depressive disorder (MDD) has been associated with disruptions in the topological organization of brain morphological networks in group-level data. Such disruptions have not yet been identified in single-patients, which is needed to show relations with symptom severity and to evaluate their potential as biomarkers for illness. To address this issue, we conducted a cross-sectional structural brain network study of 33 treatment-naive, first-episode MDD patients and 33 age-, gender-, and education-matched healthy controls (HCs). Weighted graph-theory based network models were used to characterize the topological organization of brain networks between the two groups. Compared with HCs, MDD patients exhibited lower normalized global efficiency and higher modularity in their whole-brain mo

SUBMITTER: Chen T 

PROVIDER: S-EPMC6866860 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature