Combining task-related activation and connectivity analysis of fMRI data reveals complex modulation of brain networks.

ABSTRACT: Task-related effects in functional magnetic resonance imaging (fMRI) data are usually analyzed with local activation approaches or integrative connectivity approaches, for example, by psychophysiological interaction (PPI) analysis. While both approaches are often applied to the same data set, a systematic combination of the results with a whole-brain (WB) perspective is rarely conducted and the relationship between task-dependent activation and connectivity effects is relatively unexplored. Here, we combined brain activation and graph theoretical analysis of WB-PPI results in an exemplary episodic memory data set of N = 136 healthy human participants and found regions with congruent as well as incongruent activation and connectivity changes between task and control conditions. A comparison

SUBMITTER: Gerchen MF 

PROVIDER: S-EPMC6866920 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature