Dynamic brain connectivity is a better predictor of PTSD than static connectivity.

ABSTRACT: Using resting-state functional magnetic resonance imaging, we test the hypothesis that subjects with post-traumatic stress disorder (PTSD) are characterized by reduced temporal variability of brain connectivity compared to matched healthy controls. Specifically, we test whether PTSD is characterized by elevated static connectivity, coupled with decreased temporal variability of those connections, with the latter providing greater sensitivity toward the pathology than the former. Static functional connectivity (FC; nondirectional zero-lag correlation) and static effective connectivity (EC; directional time-lagged relationships) were obtained over the entire brain using conventional models. Dynamic FC and dynamic EC were estimated by letting the conventional models to vary as a function of t

SUBMITTER: Jin C 

PROVIDER: S-EPMC6866943 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature