Interictal activity is an important contributor to abnormal intrinsic network connectivity in paediatric focal epilepsy.

ABSTRACT: Patients with focal epilepsy have been shown to have reduced functional connectivity in intrinsic connectivity networks (ICNs), which has been related to neurocognitive development and outcome. However, the relationship between interictal epileptiform discharges (IEDs) and changes in ICNs remains unclear, with evidence both for and against their influence. EEG-fMRI data was obtained in 27 children with focal epilepsy (mixed localisation and aetiologies) and 17 controls. A natural stimulus task (cartoon blocks verses blocks where the subject was told "please wait") was used to enhance the connectivity within networks corresponding to ICNs while reducing potential confounds of vigilance and motion. Our primary hypothesis was that the functional connectivity within visual and attention networ

SUBMITTER: Shamshiri EA 

PROVIDER: S-EPMC6866978 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature