The anatomical scaffold underlying the functional centrality of known cortical hubs.

ABSTRACT: Cortical hubs play a fundamental role in the functional architecture of brain connectivity at rest. However, the anatomical scaffold underlying their centrality is still under debate. Certainly, the brain function and anatomy are significantly entwined through synaptogenesis and pruning mechanisms that continuously reshape structural and functional connections. Thus, if hubs are expected to exhibit a large number of direct anatomical connections with the rest of the brain, such a dense wiring is extremely inefficient in energetic terms. In this work, we investigate these aspects on fMRI and DTI data from a set of know resting-state networks, starting from the hypothesis that to promote integration, functional, and anatomical connections link different areas at different scales or hierarchi

SUBMITTER: de Pasquale F 

PROVIDER: S-EPMC6867015 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature