Functional activation independently contributes to naming ability and relates to lesion site in post-stroke aphasia.

ABSTRACT: Language network reorganization in aphasia may depend on the degree of damage in critical language areas, making it difficult to determine how reorganization impacts performance. Prior studies on remapping of function in aphasia have not accounted for the location of the lesion relative to critical language areas. They rectified this problem by using a multimodal approach, combining multivariate lesion-symptom mapping and fMRI in chronic aphasia to understand the independent contributions to naming performance of the lesion and the activity in both hemispheres. Activity was examined during two stages of naming: covert retrieval, and overt articulation. Regions of interest were drawn based on over- and under-activation, and in areas where activity had a bivariate relationship with naming. R

SUBMITTER: Skipper-Kallal LM 

PROVIDER: S-EPMC6867020 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature