Tackling variability: A multicenter study to provide a gold-standard network approach for frontotemporal dementia.

ABSTRACT: Biomarkers represent a critical research area in neurodegeneration disease as they can contribute to studying potential disease-modifying agents, fostering timely therapeutic interventions, and alleviating associated financial costs. Functional connectivity (FC) analysis represents a promising approach to identify early biomarkers in specific diseases. Yet, virtually no study has tested whether potential FC biomarkers prove to be reliable and reproducible across different centers. As such, their implementation remains uncertain due to multiple sources of variability across studies: the numerous international centers capable conducting FC research vary in their scanning equipment and their samples' socio-cultural background, and, more troublingly still, no gold-standard method exists to ana

SUBMITTER: Sedeno L 

PROVIDER: S-EPMC6867023 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature