The norepinephrine system affects specific neurophysiological subprocesses in the modulation of inhibitory control by working memory demands.

ABSTRACT: Inhibitory control processes are known to be modulated by working memory demands. However, the neurobiological mechanisms behind these modulations are inconclusive. One important system to consider in this regard is the locus coeruleus (LC) norepinephrine (NE) system. In the current study the role of the LC-NE system by means of pupil diameter recordings that are integrated with neurophysiological (EEG) and source localization data were examined. A combined mental-rotation Go/Nogo task was used. The results show that increases in working memory load complicate response inhibition processes. On a neurophysiological level these effects were reflected by specific modulations in event-related potentials (ERPs) reflecting motor inhibition processes (i.e., Nogo-P3). Attentional selection process

SUBMITTER: Chmielewski WX 

PROVIDER: S-EPMC6867120 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature