A neuroimaging approach to capture cognitive reserve: Application to Alzheimer's disease.

ABSTRACT: Cognitive reserve (CR) explains interindividual differences in the ability to maintain cognitive function in the presence of neuropathology. We developed a neuroimaging approach including a measure of brain atrophy and cognition to capture this construct. In a group of 511 Alzheimer's disease (AD) biomarker-positive subjects in different stages across the disease spectrum, we performed 3T magnetic resonance imaging and predicted gray matter (GM) volume in each voxel based on cognitive performance (i.e. a global cognitive composite score), adjusted for age, sex, disease stage, premorbid brain size (i.e. intracranial volume) and scanner type. We used standardized individual differences between predicted and observed GM volume (i.e. W-scores) as an operational measure of CR. To validate this

SUBMITTER: van Loenhoud AC 

PROVIDER: S-EPMC6867139 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature