Toward an electrophysiological "sweet spot" for deep brain stimulation in the subthalamic nucleus.

ABSTRACT: Enhanced beta-band activity recorded in patients suffering from Parkinson's Disease (PD) has been described as a potential physiomarker for disease severity. Beta power is suppressed by Levodopa intake and STN deep brain stimulation (DBS) and correlates with disease severity across patients. The aim of the present study was to explore the promising signature of the physiomarker in the spatial domain. Based on local field potential data acquired from 54 patients undergoing STN-DBS, power values within alpha, beta, low beta, and high beta bands were calculated. Values were projected into common stereotactic space after DBS lead localization. Recorded beta power values were significantly higher at posterior and dorsal lead positions, as well as in active compared with inactive pairs. The peak

SUBMITTER: Horn A 

PROVIDER: S-EPMC6867148 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature