Abnormalities of the executive control network in multiple sclerosis phenotypes: An fMRI effective connectivity study.

ABSTRACT: The Stroop interference task is a cognitively demanding task of executive control, a cognitive ability that is often impaired in patients with multiple sclerosis (MS). The aim of this study was to compare effective connectivity patterns within a network of brain regions involved in the Stroop task performance between MS patients with three disease clinical phenotypes [relapsing-remitting (RRMS), benign (BMS), and secondary progressive (SPMS)] and healthy subjects. Effective connectivity analysis was performed on Stroop task data using a novel method based on causal Bayes networks. Compared with controls, MS phenotypes were slower at performing the task and had reduced performance accuracy during incongruent trials that required increased cognitive control. MS phenotypes also exhibited conn

SUBMITTER: Dobryakova E 

PROVIDER: S-EPMC6867262 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature