Dopaminergic receptor blockade changes a functional connectivity network centred on the amygdala.

ABSTRACT: Resting-state connectivity has become an increasingly important measure in characterizing the functional integrity of brain circuits in neuro-psychiatric conditions. One approach that has recently gained prominence in this regard-and which we use in this study-is to investigate how resting-state connectivity depends on the integrity of certain neuromodulator systems. Here, we use a pharmacological challenge in combination with functional magnetic resonance imaging to investigate the impact of dopaminergic receptor blockade on whole brain functional connectivity in twenty healthy human subjects. Administration of the D2-receptor antagonist haloperidol led to a profound change in functional integration in network nodes linked to the amygdala. Compared to placebo and baseline measurements, ne

SUBMITTER: Haaker J 

PROVIDER: S-EPMC6867368 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature