The effects of dexamphetamine on the resting-state electroencephalogram and functional connectivity.

ABSTRACT: The catecholamines-dopamine and noradrenaline-play important roles in directing and guiding behavior. Disorders of these systems, particularly within the dopamine system, are associated with several severe and chronically disabling psychiatric and neurological disorders. We used the recently published group independent components analysis (ICA) procedure outlined by Chen et al. (2013) to present the first pharmaco-EEG ICA analysis of the resting-state EEG in healthy participants administered 0.45 mg/kg dexamphetamine. Twenty-eight healthy participants between 18 and 41 were recruited. Bayesian nested-domain models that explicitly account for spatial and functional relationships were used to contrast placebo and dexamphetamine on component spectral power and several connectivity metrics. De

SUBMITTER: Albrecht MA 

PROVIDER: S-EPMC6867410 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature