Structural brain correlates of cognitive and behavioral impairment in MND.

ABSTRACT:

Objective

To assess the structural correlates of cognitive and behavioral impairment in motor neuron diseases (MND) using multimodal MRI.

Methods

One hundred one patients with sporadic MND (56 classic amyotrophic lateral sclerosis, 31 upper motor neuron phenotype, and 14 lower motor neuron phenotype) and 51 controls were enrolled. Patients were classified into MND with a pure motor syndrome (MND-motor) and with cognitive/behavioral symptoms (MND-plus). Cortical thickness measures and diffusion tensor (DT) metrics of white matter (WM) tracts were assessed. A random forest approach was used to explore the independent role of cortical and WM abnormalities in explaining major cognitive and behavioral symptoms.

Results

There were 48 MND-motor and 53 MND-plus patients. Rela

SUBMITTER: Agosta F 

PROVIDER: S-EPMC6867462 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature