Alterations in neural systems mediating cognitive flexibility and inhibition in mood disorders.

ABSTRACT: Impairment in mental flexibility may be a key component contributing to cardinal cognitive symptoms among mood disorders patients, particularly thought control disorders. Impaired ability to switch from one thought to another might reflect difficulties in either generating new mental states, inhibiting previous states, or both. However, the neural underpinnings of impaired cognitive flexibility in mood disorders remain largely unresolved. We compared a group of mood disorders patients (n = 29) and a group of matched healthy subjects (n = 32) on a novel task-switching paradigm involving happy and sad faces, that allowed us to separate generation of a new mental set (Switch Cost) and inhibition of the previous set during switching (Inhibition Cost), using fMRI. Behavioral data showed a large

SUBMITTER: Piguet C 

PROVIDER: S-EPMC6867498 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature