Accelerated longitudinal gray/white matter contrast decline in aging in lightly myelinated cortical regions.

ABSTRACT: Highly myelinated cortical regions seem to develop early and are more robust to age-related decline. By use of different magnetic resonance imaging (MRI) measures such as contrast between T1- and T2-weighted MRI scans (T1w/T2w) it is now possible to assess correlates of myelin content in vivo. Further, previous studies indicate that gray/white matter contrast (GWC) become blurred as individuals' age, apparently reflecting age-related changes in myelin structure. Here we address whether longitudinal changes in GWC are dependent on initial myelin content within tissue as defined by baseline T1w/T2w contrast, and hypothesize that lightly myelinated regions undergo more decline longitudinally. A sample of 207 healthy adult participants (range: 20-84 years) was scanned twice (interscan interval

SUBMITTER: Vidal-Pineiro D 

PROVIDER: S-EPMC6867532 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature