Computational meta-analysis of statistical parametric maps in major depression.

ABSTRACT:

Objective

Several neuroimaging meta-analyses have summarized structural brain changes in major depression using coordinate-based methods. These methods might be biased toward brain regions where significant differences were found in the original studies. In this study, a novel voxel-based technique is implemented that estimates and meta-analyses between-group differences in grey matter from individual MRI studies, which are then applied to the study of major depression.

Methods

A systematic review and meta-analysis of voxel-based morphometry studies were conducted comparing participants with major depression and healthy controls by using statistical parametric maps. Summary effect sizes were computed correcting for multiple comparisons at the voxel level. Publication bias an

SUBMITTER: Arnone D 

PROVIDER: S-EPMC6867585 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature