Threat Memory Reminder Under Matrix Metalloproteinase 9 Inhibitor Doxycycline Globally Reduces Subsequent Memory Plasticity.

ABSTRACT: Associative memory can be rendered malleable by a reminder. Blocking the ensuing reconsolidation process is suggested as a therapeutic target for unwanted aversive memories. Matrix metalloproteinase-9 (MMP-9) is required for structural synapse remodeling involved in memory consolidation. Inhibiting MMP-9 with doxycycline is suggested to attenuate human threat conditioning. Here, we investigated whether MMP-9 inhibition also interferes with threat memory reconsolidation. Male and female human participants (N = 78) learned the association between two visual conditioned stimuli (CS⁺) and a 50% chance of an unconditioned nociceptive stimulus (US), and between CS^- and the absence of US. On day 7, one CS⁺ was reminded without reinforcement 3.5 h after inge

SUBMITTER: Bach DR 

PROVIDER: S-EPMC6867817 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature