Changes in the Molecular and Functional Phenotype of Bovine Monocytes during Theileria parva Infection.

ABSTRACT: Theileria parva is the causative agent of East Coast fever (ECF), a tick-borne disease that kills over a million cattle each year in sub-Saharan Africa. Immune protection against T. parva involves a CD8⁺ cytotoxic T cell response to parasite-infected cells. However, there is currently a paucity of knowledge regarding the role played by innate immune cells in ECF pathogenesis and T. parva control. Here, we demonstrate an increase in intermediate monocytes (CD14⁺⁺ CD16⁺) with a concomitant decrease in the classical (CD14⁺⁺ CD16^-) and nonclassical (CD14⁺ CD16⁺) subsets at 12 days postinfection (dpi) during lethal infection but not during nonlethal T. parva infection. Ex vivo analyse

SUBMITTER: Bastos RG 

PROVIDER: S-EPMC6867863 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature