[Bioinformatic analysis of direct protein targets of aspirin against human breast cancer proliferation].

ABSTRACT:

Objective

To explore the molecular mechanism underlying the inhibitory effects of aspirin against human breast cancer cell proliferation through bioinformatics analysis.

Methods

Drug Bank 5.1.3 was searched to identify direct protein targets (DPTs) of aspirin, and the protein-protein interaction (PPI) network of the DPTs was constructed online using STRING and the signaling pathways involved were identified. The genetic alterations of 6 DPTs associated with human breast cancer was analyzed and visualized by cBio Portal and OncoPrint, respectively. The transcriptomic data of breast cancer and normal tissues were downloaded from TCGA database, and the overexpressed genes were analyzed by DECenter. The intersection between the genes associated with the DPTs obtained by STRING a

SUBMITTER: Zhu X 

PROVIDER: S-EPMC6867953 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature