Modeling Brain Somatic Mosaicism With Cerebral Organoids, Including a Note on Mutant Microglia.

ABSTRACT: The brain is a genomic mosaic. Cell-to-cell genomic differences, which are the result of somatic mutations during development and aging, contribute to cellular diversity in the nervous system. This genomic diversity has important implications for nervous system development, function, and disease. Brain somatic mosaicism might contribute to individualized behavioral phenotypes and has been associated with several neuropsychiatric and neurodegenerative disorders. Therefore, understanding the causes and consequences of somatic mosaicism in neural circuits is of great interest. Recent advances in 3D cell culture technology have provided new means to study human organ development and various human pathologies in vitro. Cerebral organoids ("mini-brains") are pluripotent stem cell-derived

SUBMITTER: Verheijen BM 

PROVIDER: S-EPMC6868038 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature