Hyperexcitability and impaired intracortical inhibition in patients with fragile-X syndrome.

ABSTRACT: Fragile-X syndrome (FXS) is characterized by neurological and psychiatric problems symptomatic of cortical hyperexcitability. Recent animal studies identified deficient γ-aminobutyricacid (GABA) inhibition as a key mechanism for hyperexcitability in FXS, but the GABA system remains largely unexplored in humans with the disorder. The primary objective of this study was to assess GABA-mediated inhibition and its relationship with hyperexcitability in patients with FXS. Transcranial magnetic stimulation (TMS) was used to assess cortical and corticospinal inhibitory and excitatory mechanisms in 18 patients with a molecular diagnosis of FXS and 18 healthy controls. GABA-mediated inhibition was measured with short-interval intracortical inhibition (GABA_A), long-interval intracortical

SUBMITTER: Morin-Parent F 

PROVIDER: S-EPMC6868148 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature