Compressive Remodeling Alters Fluid Transport Properties of Collagen Networks - Implications for Tumor Growth.

ABSTRACT: Biomechanical alterations to the tumor microenvironment include accumulation of solid stresses, extracellular matrix (ECM) stiffening and increased fluid pressure in both interstitial and peri-tumoral spaces. The relationship between interstitial fluid pressurization and ECM remodeling in vascularized tumors is well characterized, while earlier biomechanical changes occurring during avascular tumor growth within the peri-tumoral ECM remain poorly understood. Type I collagen, the primary fibrous ECM constituent, bears load in tension while it buckles under compression. We hypothesized that tumor-generated compressive forces cause collagen remodeling via densification which in turn creates a barrier to convective fluid transport and may play a role in tumor progression and malignancy. To bet

SUBMITTER: Ferruzzi J 

PROVIDER: S-EPMC6868165 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature