Measurements of cerebral blood volume using quantitative susceptibility mapping, R₂ * relaxometry, and ferumoxytol-enhanced MRI.

ABSTRACT: Ferumoxytol-enhanced MRI holds potential for the non-invasive assessment of vascular architecture using estimates of cerebral blood volume (CBV). Ferumoxytol specifically enables steady-state imaging with extended acquisition times, for substantial improvements in resolution and contrast-to-noise ratio. With such data, quantitative susceptibility mapping (QSM) can be used to obtain images of local tissue magnetic susceptibility and hence estimate the increase in blood susceptibility after administration of a contrast agent, which in turn can be correlated to tissue CBV. Here, we explore the use of QSM for CBV estimation and compare it with R₂ * (1/T₂ *)-based results. Institutional review board approval was obtained, and all subjects provided written informed consent.

SUBMITTER: Rivera-Rivera LA 

PROVIDER: S-EPMC6868300 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature