Chronic Systemic Inflammation Is Associated With Symptoms of Late-Life Depression: The ARIC Study.

ABSTRACT:

Objective

The current study examined how the pattern of systemic inflammation in the decades leading up to late-life relates to depression symptoms in older adults.

Methods

Within the Atherosclerosis Risk in Communities Study, we measured high-sensitivity C-reactive protein (CRP), a nonspecific marker of systemic inflammation, at three visits: 21 years and 14 years before, and concurrent with the assessment of depression symptoms, defined using the 11-item Center for Epidemiologic Studies Depression (CESD) scale. We categorized participants into one of four groups based on their 21-year longitudinal pattern of elevated (≥3 mg/L) versus low (<3 mg/L) CRP (stable low; unstable low; unstable elevated; stable elevated). Analyses excluded participants with suspected depression du

SUBMITTER: Sonsin-Diaz N 

PROVIDER: S-EPMC6868307 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature