Dataset Information

Intravitreal injection of adenosine A_2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice.

ABSTRACT: Diabetic retinopathy is a major complication of diabetes mellitus and a leading cause of blindness. The pathogenesis of diabetic retinopathy is accompanied by chronic low-grade inflammation. Evidence shows that the blockade of adenosine A_2A receptors (A_2AR) affords protection to the retina through the control of microglia-mediated neuroinflammation. Herein, we investigated the therapeutic potential of an antagonist of A_2AR in a model of diabetic retinopathy. Type 1 diabetes was induced in 4-5 months old C57BL/6 J mice with a single intraperitoneal injection streptozotocin. Animals were treated one month after the onset of diabetes. The A_2AR antagonist was delivered by intravitreal injection once a week for 4 weeks. Microglia reactivity and inflam

SUBMITTER: Aires ID

PROVIDER: S-EPMC6868354 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Intravitreal injection of adenosine A_2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Intravitreal injection of adenosine A_2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice.