Circulating plasma circular RNAs as novel diagnostic biomarkers for congenital heart disease in children.

ABSTRACT:

Objective

The diagnostic value of circulating circular RNAs (circRNAs) has received more and more attention. However, little has been reported about their potential in the diagnosis of congenital heart diseases (CHD). In this study, we explored differential expression of circRNAs from children with CHD to evaluate their potential as clinical biomarkers.

Methods

We established a discovery cohort (four CHD cases; four matched healthy controls) and a validation cohort (40 CHD cases; 40 matched healthy controls). Microarray expression analysis was performed on the discovery set to identify candidate circRNAs. Candidates were further validated in the validation set. The diagnostic accuracy of circRNAs was determined by receiver operating characteristic (ROC) analysis. Gene ontolo

SUBMITTER: Wu J 

PROVIDER: S-EPMC6868410 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature