Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet's Pathway to Prevention.

ABSTRACT:

Objective

To better understand potential facilitators of individual engagement in type 1 diabetes natural history and prevention studies through analysis of enrollment data in the TrialNet Pathway to Prevention (PTP) study.

Research design and methods

We used multivariable logistic regression models to examine continued engagement of eligible participants at two time points: 1) the return visit after screening to confirm an initial autoantibody-positive (Ab⁺) test result and 2) the initial oral glucose tolerance test (OGTT) for enrollment into the monitoring protocol.

Results

Of 5,387 subjects who screened positive for a single autoantibody (Ab), 4,204 (78%) returned for confirmatory Ab testing. Younger age was associated with increased odds o

SUBMITTER: Sims EK 

PROVIDER: S-EPMC6868467 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature