Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs.

ABSTRACT: Chromosome segregation errors during female meiosis are a leading cause of pregnancy loss and human infertility. The segregation of chromosomes is driven by interactions between spindle microtubules and kinetochores. Kinetochores in mammalian oocytes are subjected to special challenges: they need to withstand microtubule pulling forces over multiple hours and are built on centromeric chromatin that in humans is decades old. In meiosis I, sister kinetochores are paired and oriented toward the same spindle pole. It is well established that they progressively separate from each other with advancing female age. However, whether aging also affects the internal architecture of centromeres and kinetochores is currently unclear. Here, we used super-resolution microscopy to study meiotic centromere

SUBMITTER: Zielinska AP 

PROVIDER: S-EPMC6868511 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature