A qualitative transcriptional signature for the histological reclassification of lung squamous cell carcinomas and adenocarcinomas.

ABSTRACT:

Background

Targeted therapy for non-small cell lung cancer is histology dependent. However, histological classification by routine pathological assessment with hematoxylin-eosin staining and immunostaining for poorly differentiated tumors, particularly those from small biopsies, is still challenging. Additionally, the effectiveness of immunomarkers is limited by technical inconsistencies of immunostaining and lack of standardization for staining interpretation.

Results

Using gene expression profiles of pathologically-determined lung adenocarcinomas and squamous cell carcinomas, denoted as pADC and pSCC respectively, we developed a qualitative transcriptional signature, based on the within-sample relative gene expression orderings (REOs) of gene pairs, to distinguish ADC from

SUBMITTER: Li X 

PROVIDER: S-EPMC6868745 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature