MicroRNAs in Pancreatic Cancer: biomarkers, prognostic, and therapeutic modulators.

ABSTRACT: A severe lack of early diagnosis coupled with resistance to most available therapeutic options renders pancreatic cancer as a major clinical concern. The limited efficacy of current treatments necessitates the development of novel therapeutic strategies that are based on an understanding of the molecular mechanisms involved in pancreatic cancer progression. MicroRNAs (miRNAs) are non-coding small RNAs that regulate the expression of multiple proteins in the post-translation process and thus have promise as biomarkers, prognostic agents, and as advanced pancreatic therapies. Profiling of deregulated miRNAs in pancreatic cancer can correlate to diagnosis, indicate optimal treatment and predict response to therapy. Furthermore, understanding the main effector genes in pancreatic cancer along

SUBMITTER: Daoud AZ 

PROVIDER: S-EPMC6868851 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature