Ontology highlight
ABSTRACT:
SUBMITTER: Lhoumaud P
PROVIDER: S-EPMC6868874 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Genome biology 20191121 1
Activation of regulatory elements is thought to be inversely correlated with DNA methylation levels. However, it is difficult to determine whether DNA methylation is compatible with chromatin accessibility or transcription factor (TF) binding if assays are performed separately. We developed a fast, low-input, low sequencing depth method, EpiMethylTag, that combines ATAC-seq or ChIP-seq (M-ATAC or M-ChIP) with bisulfite conversion, to simultaneously examine accessibility/TF binding and methylatio ...[more]