Physicochemical and Antibacterial Properties of PEGylated Zinc Oxide Nanoparticles Dispersed in Peritoneal Dialysis Fluid.

ABSTRACT: Owing to the peculiar broad-spectrum antimicrobial activities of zinc oxide nanoparticles (ZnO NPs), we envisaged their use to treat bacterial/mycobacterial/fungal infections during peritoneal dialysis (PD) of end-stage renal failure patients. However, a recent study from our lab showed that ZnO-NPs cannot be employed for the same in their naked form owing to their rapid agglomeration. Also, the naked ZnO-NPs showed strong interaction with organic acids present in the PD fluid (i.e., lactate and citrate present abundantly in almost all biological fluids) resulting in the formation of bioconjugates. Here, we propose that the surface coating of ZnO NPs may inhibit the binding interactions of NPs with the constituents of PD fluid. Therefore, in this study, we have carried out the surface coat

SUBMITTER: Pranjali P 

PROVIDER: S-EPMC6868886 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature