Measurement and genetics of human subcortical and hippocampal asymmetries in large datasets.

ABSTRACT: Functional and anatomical asymmetries are prevalent features of the human brain, linked to gender, handedness, and cognition. However, little is known about the neurodevelopmental processes involved. In zebrafish, asymmetries arise in the diencephalon before extending within the central nervous system. We aimed to identify genes involved in the development of subtle, left-right volumetric asymmetries of human subcortical structures using large datasets. We first tested the feasibility of measuring left-right volume differences in such large-scale samples, as assessed by two automated methods of subcortical segmentation (FSL|FIRST and FreeSurfer), using data from 235 subjects who had undergone MRI twice. We tested the agreement between the first and second scan, and the agreement between th

SUBMITTER: Guadalupe T 

PROVIDER: S-EPMC6869341 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature