Interactions between glutamate, dopamine, and the neuronal signature of response inhibition in the human striatum.

ABSTRACT: Response inhibition is a basic mechanism in cognitive control and dysfunctional in major psychiatric disorders. The neuronal mechanisms are in part driven by dopamine in the striatum. Animal data suggest a regulatory role of glutamate on the level of the striatum. We used a trimodal imaging procedure of the human striatum including F18-DOPA positron emission tomography, proton magnetic resonance spectroscopy, and functional magnetic resonance imaging of a stop signal task. We investigated dopamine synthesis capacity and glutamate concentration in vivo and their relation to functional properties of response inhibition. A mediation analysis revealed a significant positive association between dopamine synthesis capacity and inhibition-related neural activity in the caudate nucleus. This relat

SUBMITTER: Lorenz RC 

PROVIDER: S-EPMC6869374 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature