The trajectory of disturbed resting-state cerebral function in Parkinson's disease at different Hoehn and Yahr stages.

ABSTRACT:

Objective

We aim to investigate the disturbance of neural network associated with the different clinical stages of Parkinson's disease (PD).

Method

We recruited 80 patients at different H&Y stages of PD (28 at H&Y stage I, 28 at H&Y stage II, 24 at H&Y stage III) and 30 normal controls. All participants underwent resting-state fMRI scans on a 3-T MR system. The amplitude of low-frequency fluctuation (ALFF) of blood oxygen level-dependent signals was used to characterize regional cerebral function. Functional integration across the brain regions was evaluated by a seed voxel correlation approach.

Results

PD patients had decreased regional activities in left occipital and lingual regions; these regions show decreased functional connection pattern with temporal regions,

SUBMITTER: Luo C 

PROVIDER: S-EPMC6869419 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature