Changes in intrinsic connectivity of the brain's reading network following intervention in children with autism.

ABSTRACT: While task-based neuroimaging studies have identified alterations in neural circuitry underlying language processing in children with autism spectrum disorders [ASD], resting state functional magnetic resonance imaging [rsfMRI] is a promising alternative to the constraints posed by task-based fMRI. This study used rsfMRI, in a longitudinal design, to study the impact of a reading intervention on connectivity of the brain regions involved in reading comprehension in children with ASD. Functional connectivity was examined using group independent component analysis (GICA) and seed-based correlation analysis of Broca's and Wernicke's areas, in three groups of participants: an experimental group of ASD children (ASD-EXP), a wait list control group of ASD children (ASD-WLC), and a group of typic

SUBMITTER: Murdaugh DL 

PROVIDER: S-EPMC6869516 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature