Bioreactor-manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies.

ABSTRACT:

Objectives

Bioreactor-based production systems have the potential to overcome limitations associated with conventional tissue engineering manufacturing methods, facilitating regulatory compliant and cost-effective production of engineered grafts for widespread clinical use. In this work, we established a bioreactor-based manufacturing system for the production of cartilage grafts.

Materials & methods

All bioprocesses, from cartilage biopsy digestion through the generation of engineered grafts, were performed in our bioreactor-based manufacturing system. All bioreactor technologies and cartilage tissue engineering bioprocesses were transferred to an independent GMP facility, where engineered grafts were manufactured for two large animal studies.

Results

The results of

SUBMITTER: Vukasovic A 

PROVIDER: S-EPMC6869519 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature