Predictors of coupling between structural and functional cortical networks in normal aging.

ABSTRACT: Understanding how the mammalian neocortex creates cognition largely depends on knowledge about large-scale cortical organization. Accumulated evidence has illuminated cortical substrates of cognition across the lifespan, but how topological properties of cortical networks support structure-function relationships in normal aging remains an open question. Here we investigate the role of connections (i.e., short/long and direct/indirect) and node properties (i.e., centrality and modularity) in predicting functional-structural connectivity coupling in healthy elderly subjects. Connectivity networks were derived from correlations of cortical thickness and cortical glucose consumption in resting state. Local-direct connections (i.e., nodes separated by less than 30 mm) and node modularity (i.e.,

SUBMITTER: Romero-Garcia R 

PROVIDER: S-EPMC6869592 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature