The neural basis of the abnormal self-referential processing and its impact on cognitive control in depressed patients.

ABSTRACT: Persistent pondering over negative self-related thoughts is a central feature of depressive psychopathology. In this study, we sought to investigate the neural correlates of abnormal negative self-referential processing (SRP) in patients with Major Depressive Disorder and its impact on subsequent cognitive control-related neuronal activation. We hypothesized aberrant activation dynamics during the period of negative and neutral SRP in the rostral anterior cingulate cortex (rACC) and in the amygdala in patients with major depressive disorder. Additionally, we assumed abnormal activation in the fronto-cingulate network during Stroop task execution. 19 depressed patients and 20 healthy controls participated in the study. Using an event-related functional magnetic resonance imaging (fMRI) desi

SUBMITTER: Wagner G 

PROVIDER: S-EPMC6869596 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature