Hippocampal (subfield) volume and shape in relation to cognitive performance across the adult lifespan.

ABSTRACT: Newer approaches to characterizing hippocampal morphology can provide novel insights regarding cognitive function across the lifespan. We comprehensively assessed the relationships among age, hippocampal morphology, and hippocampal-dependent cognitive function in 137 healthy individuals across the adult lifespan (18-86 years of age). They underwent MRI, cognitive assessments and genotyping for Apolipoprotein E status. We measured hippocampal subfield volumes using a new multiatlas segmentation tool (MAGeT-Brain) and assessed vertex-wise (inward and outward displacements) and global surface-based descriptions of hippocampus morphology. We examined the effects of age on hippocampal morphology, as well as the relationship among age, hippocampal morphology, and episodic and working memory perf

SUBMITTER: Voineskos AN 

PROVIDER: S-EPMC6869683 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature