Combined neuroimaging and gene expression analysis of the genetic basis of brain plasticity indicates across species homology.

ABSTRACT: Brain plasticity and memory formation depend on the expression of a large number of genes. This relationship had been studied using several experimental approaches and researchers have identified genes regulating plasticity through a variety of mechanisms. Despite this effort, a great deal remains unknown regarding the role of different genes in brain plasticity. Previous studies usually focused on specific brain structures and many of the genes influencing plasticity have yet to be identified. In this work, we integrate results of in vivo neuroimaging studies of plasticity with whole-brain gene expression data for the study of neuroplasticity. Brain regions, found in the imaging study to be involved in plasticity, are first spatially mapped to the anatomical framework of the genetic datab

SUBMITTER: Dinai Y 

PROVIDER: S-EPMC6869696 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature