Altered prefrontal activity and connectivity predict different cognitive deficits in schizophrenia.

ABSTRACT:

Background

Cognitive dysfunction is considered a core feature of schizophrenia, and impaired performances in episodic memory (EM) and executive function (EF) tasks are consistently reported in schizophrenia patients. Traditional fMRI and EEG studies have helped identifying brain areas, including the prefrontal cortex (PFC), involved in these tasks. However, it is unclear whether intrinsic defects in prefrontal function per se contribute to poor performance in schizophrenia, given the presence of confounds like reduced motivation and psychotic symptoms. TMS/hd-EEG measurements are obtained without cognitive effort, and can be calculated in any cortical area.

Methods

We performed TMS/hd-EEG recordings in parietal, motor, premotor, and PFC in healthy individuals (N=20) and schi

SUBMITTER: Ferrarelli F 

PROVIDER: S-EPMC6869713 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature