Effects of age and Alzheimer's disease on hippocampal subfields: comparison between manual and FreeSurfer volumetry.

ABSTRACT: Growing interest has developed in hippocampal subfield volumetry over the past few years and an increasing number of studies use the automatic segmentation algorithm implemented in FreeSurfer. However, this approach has not been validated on standard resolution T1-weighted magnetic resonance (MR) as used in most studies. We aimed at comparing hippocampal subfield segmentation using FreeSurfer on standard T1-weighted images versus manual delineation on dedicated high-resolution hippocampal scans. Hippocampal subfields were segmented in 133 individuals including 98 cognitively normal controls aged 19-84 years, 17 mild cognitive impairment and 18 Alzheimer's disease (AD) patients using both methods. Intraclass correlation coefficients (ICC) and Bland-Altman plots were computed to assess the c

SUBMITTER: de Flores R 

PROVIDER: S-EPMC6869780 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature